Sickle Cell Anaemia (SCA) is the most common inherited blood disorder and is associated with severe morbidity and decreased survival.Allogeneic Haematopoietic Stem Cell Transplantation (HSCT) is the only curative approach.Nevertheless the decision to perform a marrow transplant includes the risk of major complications and mortality transplant relat
Integrating tacrolimus into eutectic oil-based microemulsion for atopic dermatitis: simultaneously enhancing percutaneous delivery and treatment efficacy with relieving side effects
Yixuan Wang, Sisi Cao, Kaiyue Yu, Fengdie Yang, Xiuming Yu, Yuanhao Zhai, Chuanbin Wu, Yuehong XuDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People’s Republic of ChinaBackground: Topical application of tacrolimus (FK506) was effective in treating atopic dermatitis (AD); however, th
Gapless assembly of maize chromosomes using long-read technologies
Abstract Creating gapless Lanyards telomere-to-telomere assemblies of complex genomes is one of the ultimate challenges in genomics.We use two independent assemblies and an optical map-based merging pipeline to produce a maize genome (B73-Ab10) composed of 63 contigs and a contig N50 of 162 Mb.This genome includes gapless assemblies of chromosome 3
A cross sectional study on reproductive health disorders in dairy cattle in Sudan
A cross sectional survey was carried out in dairy farms in four States of Sudan to determine prevalence of reproductive health disorders Footballs that affect dairy cattle industries in the country.A total of 575 adult female cows in dairy farms located in Khartoum, Gezira, Sennar, and White Nile States were investigated using questionnaire survey
COVID-19 knowledge, attitudes and practices survey among population of Western Maharashtra
Background: In wake of COVID-19 pandemic in India, basic knowledge of mode of transmission of the disease, precautionary hygiene practices to be adopted to contain the infection and specific dietary modifications to be made as per government advisories are critical from public health and safety viewpoint.Objective: The objective is to find out the